Symbol
Name
ID

Tet2
tet methylcytosine dioxygenase 2
MGI:2443298

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Acute myeloid leukemia	Myelodysplasia
Disease(s) Associated with TET2	Acute myeloid leukemia	Myelodysplasia
acute myeloid leukemia
myelodysplastic syndrome

Mouse Phenotypes

abnormal monocyte differentiation

increased DN1 thymic pro-T cell number

enlarged spleen

increased spleen weight

abnormal definitive hematopoiesis

abnormal common myeloid progenitor cell morphology

abnormal erythropoiesis

decreased pro-B cell number

increased double-negative T cell number

abnormal myelopoiesis

myeloid hyperplasia

extramedullary hematopoiesis

anemia

increased bone marrow cell number

increased erythroid progenitor cell number

abnormal proerythroblast morphology

increased erythroblast number

decreased erythrocyte cell number

increased erythrocyte cell number

increased hemoglobin content

increased neutrophil cell number

increased granulocyte number

thrombocytopenia

decreased B cell number

decreased pre-B cell number

increased B cell number

increased monocyte cell number

increased leukocyte cell number

increased hematopoietic cell number

increased hematopoietic stem cell number

abnormal myeloid leukocyte morphology

abnormal spleen morphology

increased spleen red pulp amount

increased splenocyte number

abnormal hematopoietic stem cell physiology

Availability

Mouse Genotype

Tet2^{Gt(AN0709)Wtsi}/Tet2^{Gt(AN0709)Wtsi}

Tet2^tm1.1Mjxu/Tet2^tm1.1Mjxu

Tet2^tm1.2Rao/Tet2^tm1.2Rao

Tet2^{Gt(AN0709)Wtsi}/Tet2⁺

Tet2^tm1.1Mjxu/Tet2⁺

Tet2^tm1.1Iaai/Tet2^tm1.1Iaai
Tg(Mx1-cre)1Cgn/0 (conditional)

Tet2^tm1.1Iaai/Tet2^tm1.1Iaai
Tg(VAV1-cre)1Graf/0 (conditional)

Tet2^tm1Ics/Tet2^tm1Ics
Tg(Mx1-cre)1Cgn/0 (conditional)

Tet2^tm1.1Iaai/Tet2⁺
Tg(VAV1-cre)1Graf/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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